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Home > LYM NHL B-cell PCNSL - R-MP [RITUximab, metHOTREXATe and procarbazine] followed by procarbazine maintenance [65 years and over] > LYM - procarbazine [100 mg daily for 5 days]
This regimen is a component of LYM NHL B-cell PCNSL - R-MP [RITUximab, metHOTREXATe and procarbazine] followed by procarbazine maintenance [65 years and over]

procarbazine maintenance (LYM NHL B-cell PCNSL - R-MP [RITUximab, metHOTREXATe and procarbazine] followed by procarbazine maintenance [65 years and over])

Treatment Overview

Follows R-MP after complete response.

Start on day 43 of last R-MP cycle.

Cycles 1 to 6 - 28 days

Cycle length:
28

Cycle details

Cycles 1 to 6 - 28 days

Medication Dose Route Days Max Duration
procarbazine 100 mg flat dosing Once daily oral administration 1 to 5

Full details

Cycles 1 to 6 - 28 days

Day: 1

Medication Dose Route Max duration Details
procarbazine 100 mg flat dosing Once daily oral administration
Instructions:
  • Take at night with food.
  • Do not drink alcohol and avoid large amounts of tyramine-rich foods (e.g. aged cheeses, cured meats, fermented foods and yeast extracts such as Marmite®) while being treated with this medicine. Talk to your doctor or pharmacist before taking medicines purchased over the counter from a pharmacy, supermarket or health food store.
  • Round dose to closest multiple of 50 mg capsules.

Day: 2

Medication Dose Route Max duration Details
procarbazine 100 mg flat dosing Once daily oral administration
Instructions:
  • Take at night with food.
  • Do not drink alcohol and avoid large amounts of tyramine-rich foods (e.g. aged cheeses, cured meats, fermented foods and yeast extracts such as Marmite®) while being treated with this medicine. Talk to your doctor or pharmacist before taking medicines purchased over the counter from a pharmacy, supermarket or health food store.
  • Round dose to closest multiple of 50 mg capsules.

Day: 3

Medication Dose Route Max duration Details
procarbazine 100 mg flat dosing Once daily oral administration
Instructions:
  • Take at night with food.
  • Do not drink alcohol and avoid large amounts of tyramine-rich foods (e.g. aged cheeses, cured meats, fermented foods and yeast extracts such as Marmite®) while being treated with this medicine. Talk to your doctor or pharmacist before taking medicines purchased over the counter from a pharmacy, supermarket or health food store.
  • Round dose to closest multiple of 50 mg capsules.

Day: 4

Medication Dose Route Max duration Details
procarbazine 100 mg flat dosing Once daily oral administration
Instructions:
  • Take at night with food.
  • Do not drink alcohol and avoid large amounts of tyramine-rich foods (e.g. aged cheeses, cured meats, fermented foods and yeast extracts such as Marmite®) while being treated with this medicine. Talk to your doctor or pharmacist before taking medicines purchased over the counter from a pharmacy, supermarket or health food store.
  • Round dose to closest multiple of 50 mg capsules.

Day: 5

Medication Dose Route Max duration Details
procarbazine 100 mg flat dosing Once daily oral administration
Instructions:
  • Take at night with food.
  • Do not drink alcohol and avoid large amounts of tyramine-rich foods (e.g. aged cheeses, cured meats, fermented foods and yeast extracts such as Marmite®) while being treated with this medicine. Talk to your doctor or pharmacist before taking medicines purchased over the counter from a pharmacy, supermarket or health food store.
  • Round dose to closest multiple of 50 mg capsules.

Supportive Care Factors

Factor Value
Antiviral prophylaxis for hepatitis B virus: Required for anti–HBc positive patients at risk of reactivation
Emetogenicity: Medium to high

References

No references

* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.

s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.